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Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR
Publication date:
1 Apr 2015
Ref:
Occup Med (Lond). 2015; 65(3): 256-8.
Author(s):
Cannon J, Fitzgerald B, Seed M, Agius R, Jiwany A, Cullinan P.
Publication type:
Article
Abstract:
We report occupational asthma and rhinitis in a formulation pharmacist, employed in the development of tafenoquine. Tafenoquine is a new anti-malarial drug in development; the pure drug substance has an asthma hazard index of zero and previously was not known to be a respiratory sensitizing agent. The implications of this finding for the refinement of quantitative structural analysis of asthmagenic chemicals are discussed.