Dr Jennifer Canizales
Dr Jennifer Canizales
Laboratory Development Manager
Dr. Jennifer Canizales runs the Occupational and Environmental Medicine Lab Service at the National Heart and Lung Institute (NHLI), where she oversees diagnostic services for occupational respiratory diseases. Her work focuses on developing new immunological assays and collaborating with researchers at Imperial College and other institutions on environmental health research.
Prior to this, Jennifer worked on malaria serosurveillance projects at the London School of Hygiene & Tropical Medicine and contributed to allergy research with the SPIRAL study at Imperial College London. Today, she combines lab management with ongoing research to improve diagnostic techniques in occupational respiratory disease.
- Phone: +44 (0)207 594 7930
- Email: j.canizales@imperial.ac.uk
- ORCID: 0000-0003-1329-3060
- See a list of recent publications by Dr Jennifer Canizales
Laboratory animal allergy is preventable in modern research facilities
Measurement of specific IgG4 anti-mouse urine antibodies
IgG4 and its role in immune tolerance has been investigated widely. Symptom reduction and improved clinical outcomes in immunotherapy trials are associated with significant increases in allergen-specific IgG4 antibodies. Natural immune tolerance observed in beekeepers and cat owners has also been associated with elevated levels of bee venom and cat allergen-specific IgG4, respectively. Functionally, allergen-specific IgG4 has been shown to reduce the binding of IgE-allergen complexes to B cells, a key step in the initiation of the type 1 hypersensitivity allergic response.
