Publications

IgG4 and its role in immune tolerance has been investigated widely. Symptom reduction and improved clinical outcomes in immunotherapy trials are associated with significant increases in allergen-specific IgG4 antibodies. Natural immune tolerance observed in beekeepers and cat owners has also been associated with elevated levels of bee venom and cat allergen-specific IgG4, respectively. Functionally, allergen-specific IgG4 has been shown to reduce the binding of IgE-allergen complexes to B cells, a key step in the initiation of the type 1 hypersensitivity allergic response.

Laboratory animal allergy (LAA) results from occupational ex-posure to allergens found in the hair, dander, urine, and salivaof laboratory animals. It presents as work-related rhinocon-junctivitis and occupational asthma after a latency period of2–3 years. Prevalence of rodent-sensitisation among laboratoryanimal (LA) workers ranges between 10.4% [1] and 28% [2].Though exposure is a major risk factor, some individuals developallergen-specific IgE without progressing to LAA symptoms andare considered clinically tolerant [3].